Research Article Open Access

HIV-1-Specific CTL Recognizing a Scarce Epitope Are Not Suppressed by HIV-1 Protease Inhibitors

Otto O. Yang1
  • 1 University of California, United States

Abstract

HIV-1-protease inhibitors have received growing attention as agents that can affect proteases in human proteasomes, with potentially deleterious effects for HIV-1-specific cellular immunity. Studying the antiviral activity of HIV-1-specific CTL that recognize an epitope that is presented at limiting concentrations on infected cells, we find that several HIV-1 protease inhibitors do not affect their function. These data indicate that these protease inhibitors may have minimal impact on the antiviral activity of CTL.

American Journal of Immunology
Volume 3 No. 1, 2007, 1-3

DOI: https://doi.org/10.3844/ajisp.2007.1.3

Submitted On: 19 January 2007 Published On: 30 June 2007

How to Cite: Yang, O. O. (2007). HIV-1-Specific CTL Recognizing a Scarce Epitope Are Not Suppressed by HIV-1 Protease Inhibitors. American Journal of Immunology, 3(1), 1-3. https://doi.org/10.3844/ajisp.2007.1.3

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Keywords

  • HIV
  • HLA class I antigens
  • protease inhibitor
  • antiviral immunity