Evaluation of A Rapid IgM-IgG Combined Antibody Test for SARS-CoV-2 Infection: Single Italian Center Study
- 1 Altamedica Main Centre, Italy
- 2 Fetal-Maternal Medical Centre, Italy
Abstract
The need for timely establishment of diagnostic assays of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is demanded in laboratories worldwide. We evaluated the performance of a flow immunoassay which can detect IgM an IgG antibodies simultaneously against SARS-CoV-2 virus in human blood within 15 min. Among the 132 positive novel Coronavirus Disease 19 (COVID-19) cases, 126 tests were consistent with previous quantitative Real Time PCR (qRT-PCR) assays. Among the 62 negative cases, 60 were consistent with qRT-PCR assays except for 2 cases. In this study, 2019-nCOV/COVID-19 IgG/IgM Rapid Test Device showed 95.5% sensitivity and 96.8% specificity. In conclusion, Rapid IgM-IgG Combined Antibody Test showed high detection consistency among all analysed samples. Suggesting that could be used for the rapid screening of SARS-CoV-2 carriers, either symptomatic or asymptomatic.
DOI: https://doi.org/10.3844/ajidsp.2020.85.88
Copyright: © 2020 Katia Margiotti, Marina Cupellaro, Sabrina Emili, Alvaro Mesoraca and Claudio Giorlandino. This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
- Rapid IgM-IgG Combined Antibody Test
- Novel Coronavirus Disease 19 (COVID-19)