Direct Acting Anti-Viral Drugs Improve Health-Related Quality of Life in Patients' with Hepatitis C
- 1 Menoufia University, Egypt
Abstract
Chronic hepatitis C Virus (HCV) causes significant decline in the Health Related Quality of Life (HRQL). Recently, direct Acting Anti-viral Drugs (DAA) have been endorsed as standard of care for treatment for HCV. To study the HRQL in patients with HCV and cirrhosis before and after DAA. Study design: Prospective cohort hospital based study. We included 500 patients with HCV and cirrhosis fulfilled all eligibility criteria for treatment and completed the survey of HRQL using (SF-36 and CLDQ questioners) before and after treatment. Patients were treated by combination of one of the following regimens: (a) Sofosbuvir (SOF) plus Daclatasvir (DAC) ± Ribavirin (RBV) in 2 divided doses or (b) SOF plus Simeprevir (SIM) ± RBV or c) SOF plus RBV. On treatment, 35.2% of the patients had a poor physical function and half of them had poor role-emotional, while 45.7% patients’ had excellent role-emotional, 49% noticed change in their mode, evaluation of HRQL before and after treatment through SF-36 and CLDQ showed an improvement in different domains. (p<0.05). The overall Sustained Virological Response (SVR) was (89.6%). Results from the current study suggest that HRQL decreased on treatment and significantly increased after treatment. We recommend addressing the patients’ quality of life into consideration as a part of the evaluation protocol before the initiation of DAA drugs and after cure to improve this particular aspect of patients’ life.
DOI: https://doi.org/10.3844/ajidsp.2020.44.54
Copyright: © 2020 Wesam Morad, Warda Othman, Esam Elshimi and Nashwa Shebl. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- HCV
- DAA Drugs
- Liver Cirrhosis
- Quality of Life