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Frequency: Quarterly
ISSN: 1553-6203 (Print)
ISSN: 1558-6340 (Online)
Research Article Open Access

Monocytes and their Role in Human Immunodeficiency Virus Pathogenesis

Tara Sassé1, Jingqin Wu1, Li Zhou1 and Nitin K. Saksena1
  • 1 University of Sydney Westmead, Australia

Abstract

Monocytes play several significant immunological roles during HIV infection. The phenotypic pliability and the cellular differentiation ability monocytes possess are crucial to the ways they combat infections and control inflammatory processes. The purpose of this review is to provide a comprehensive snapshot of the importance of monocytes in HIV-1 infection and pathogenesis. Moreover, this review also provides newly emerging data on how HIV leads to the subversion and manipulation of monocyte transcriptome and proteome, which may have implications in understanding the genomic and proteomic basis of monocyte function and its interaction with HIV.

American Journal of Infectious Diseases
Volume 8 No. 2, 2012, 92-105

DOI: https://doi.org/10.3844/ajidsp.2012.92.105

Submitted On: 31 May 2012 Published On: 31 July 2012

How to Cite: Sassé, T., Wu, J., Zhou, L. & Saksena, N. K. (2012). Monocytes and their Role in Human Immunodeficiency Virus Pathogenesis. American Journal of Infectious Diseases, 8(2), 92-105. https://doi.org/10.3844/ajidsp.2012.92.105

Open AccessCopyright: © 2012 Tara Sassé, Jingqin Wu, Li Zhou and Nitin K. Saksena. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Dendritic Cells (DCs)
  • Human Immunodeficiency Virus (HIV)
  • Tumor Necrosis Factor (TNF)
  • Natural Killer (NK)
  • Lipopolysaccharide (LPS)