Research Article Open Access

Correlation of IFN-Inducible Protein 10 Levels in Sera with Disease Severity and Clinical Outcome of the Dengue Patients

Ying-Ray Lee1, Nguyen-Thanh Hung2, Ching-Chuan Liu3, Kao-Jean Huang3, Huan-Yao Lei3, Yee-Shin Lin3, Jen-Reng Wang3, Trai-Ming Yeh3, Shun-Hua Chen3 and Hsiao-Sheng Liu3
  • 1 Institute of Basic Medical Sciences, Vietnam
  • 2 Children’s Hospital No. 1, Ho Chi Minh City, Vietnam
  • 3 National Cheng Kung University, Taiwan

Abstract

Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF/DSS, which is different from the expression profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the severity of dengue disease.

American Journal of Infectious Diseases
Volume 4 No. 1, 2008, 18-21

DOI: https://doi.org/10.3844/ajidsp.2008.18.21

Submitted On: 9 August 2007 Published On: 31 March 2008

How to Cite: Lee, Y., Hung, N., Liu, C., Huang, K., Lei, H., Lin, Y., Wang, J., Yeh, T., Chen, S. & Liu, H. (2008). Correlation of IFN-Inducible Protein 10 Levels in Sera with Disease Severity and Clinical Outcome of the Dengue Patients. American Journal of Infectious Diseases, 4(1), 18-21. https://doi.org/10.3844/ajidsp.2008.18.21

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Keywords

  • IP-10
  • dengue virus