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Frequency: Quarterly
ISSN: 1553-6203 (Print)
ISSN: 1558-6340 (Online)
Research Article Open Access

Retinoids and Opioids: Factors in the Development of HIV-Related Neurological Disease

Walter Royal, III1 and Joseph L. Bryant2
  • 1 University of Maryland School of Medicine, United States
  • 2 University of Maryland, United States

Abstract

Neurological disease occurs frequently in HIV-infected individuals and may occur at even higher rates among infected drug users. Among the potential mechanisms that promote such impairment, retinoid deficiency may have selective effects that could both lead to alterations in immune function and enhanced replication of HIV. Studies are currently underway to examine the possible selective effects of retinoid receptor activation and interactions with opioids on the pathogenesis of neurological disease in the transgenic rat model of HIV infection.

American Journal of Infectious Diseases
Volume 4 No. 2, 2008, 140-146

DOI: https://doi.org/10.3844/ajidsp.2008.140.146

Submitted On: 24 June 2007 Published On: 30 June 2008

How to Cite: Royal, III, W. & Bryant, J. L. (2008). Retinoids and Opioids: Factors in the Development of HIV-Related Neurological Disease. American Journal of Infectious Diseases, 4(2), 140-146. https://doi.org/10.3844/ajidsp.2008.140.146

Open AccessCopyright: © 2008 Walter Royal, III and Joseph L. Bryant. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • retinoids
  • opioids
  • retinoid receptors
  • HIV-1
  • neuro-AIDS
  • nervous system